Tingling or burning sensations in the limbs, medically termed paresthesia, can arise from a variety of underlying causes. These sensations often result from nerve irritation or damage, which can occur due to conditions such as peripheral neuropathy, diabetes, carpal tunnel syndrome, or vitamin deficiencies, particularly vitamin B12. Compressed nerves from prolonged pressure, repetitive movements, or injury can also lead to these uncomfortable sensations. Systemic conditions like multiple sclerosis or autoimmune diseases may contribute as well. Managing paresthesia involves identifying and treating the underlying cause, which may include lifestyle modifications, physical therapy, medications, or surgical interventions to alleviate pressure on affected nerves.